DeNese began her career as a labor and delivery nurse in 1987. After starting a family and gaining experience as an RN she enrolled in the CNEP program at Frontier. She graduated from Frontier in 2013. She works as a full-scope nurse-midwife for Cherokee Nation in Tahlequah, OK. DeNese continues to serve the Cherokee Nation. She is now focusing on her role as Regional Clinical Faculty for AR, KS, OK, MO, and NM. The completion of her Doctor of Nursing Practice was accomplished on June 22, 2018. In her free time, she enjoys gardening and spending time with her husband, five children, and grandbabies.